Nourtan Abdeltawab

My responsibilities include organizing scientific workshops that BTC offers to scientific societies. Workshops are one of the three main branches of activities that BTC offers. The other two branches are research and quality control.

-Supervised graduate teaching assistant in teaching practical microbiology and immunology for undergraduate students. -Mentored three post-graduate students in introduction to systems biology and bioinformatics. -Organized and held workshop on systems biology approaches and its applications – This workshop drew revenue for Faculty of Pharmacy Biotechnology Center – Attendees were from different universities and institutes in Egypt – This workshop was highly rated by attendees.

• Postdoctoral Training: o Mapped quantitative trait loci (QTLs) associated with differential host responses to Ebola and Shiga-toxin producing E. coli. (Zumbrun EE et al., 2012; Russo LM et al., 2015) (complete list below) -Performed studies towards elucidating the role and mechanism of prostaglandin E2 in modulating host differential susceptibility to severe GAS sepsis in collaboration with Dr. David Aronoff at University of Michigan, Ann Arbor, MI. o Conducted genome-wide transcriptional profiling of mouse and human cell lines to identify conserved genetic pathways. Deposited data in GeneNetwork to facilitate translational research. -Designed and analyzed genome-wide association studies (GWAS) with multiple collaborators studying differential host response to various diseases. These collaborations resulted in mapping quantitative trait loci (QTLs) associated with differential response to a number of infectious diseases including the following projects: - Shiga toxin with Dr. Angela Melton-Celsa & Dr. Alison O'Brien - Herpes simplex virus with Dr. Nancy Swatell & Dr. Richard Thompson - Select BSL3 agents - Traumatic injury immune responses in CLP-induced sepsis studies with Dr. Charles Caldwell - Differential response to asthma with Dr. Marsha Karp & Dr. Ian Lewkowich Supervisory Experience -Supervised two technicians for breeding and maintenance of BXD mice strain panel. -Managed mouse colony of recombinant inbred, transgenic and congenic mice, generated an efficient FileMaker Pro mouse colony database. I reduced the number of cages and the increased efficiency of breeding leading to saving in monthly expenses of mouse colony and higher efficiency in use of mice. -Supervised two graduate and three undergraduate students

Dissertation title: Systems biology approach to identifying host interactive pathways modulating the severity of streptococcal sepsis. Advisor: Malak Y. Kotb – Committee: Linda M. Hendershot, Tony N. Marion, David R. Nelson, Robert W. Williams. -Worked towards identifying host immune pathways modulating differential susceptibility to streptococcal sepsis. This was done by applying a systems genetics approach, performing genome-wide association studies (GWAS) and linking phenotypic variation in host responses to variations in genotypes. -Standardized a mouse model of streptococcal sepsis using advanced recombinant inbred (ARI) panel of BXD mouse strains (Aziz et al 2007). These are a genetically diverse reference population that we used to mimic the genetic diversity of human population. -Mapped quantitative trait loci (QTLs) associated with differential host response to sepsis and parsed them into network of pathways (Abdeltawab et al 2008). -Led teams in my mentor’s laboratory as part of several high-throughput collaborations including: -High-throughput genome-wide transcriptional profiling of mouse spleen across BXD and common inbred mouse strains, completed project was deposited in GeneNetwork online platform February 2010. URL: http://www.genenetwork.org/dbdoc/UTHSC_SPL_RMA_1210.html -High-throughput genome-wide transcriptional profiling CEPH panel (Centre d'Etude du Polymorphisme Humain). Completed project was deposited in GeneNetwork online platform September 2009. URL: http://www.genenetwork.org/dbdoc/UT_CEPH_RankInv0909.html -Standardized several procedures in the laboratory and wrote Standard Operating Procedures (SOP). Supervisory Experience -Supervised four technicians working on high-throughput collaboration listed above. -Moving and Setting up the laboratory after relocation from UTHSC, Memphis, TN to UC, Cincinnati, OH. -Supervised three graduate students and a visiting medical student.